Postdoctoral Research Scientist Pharmacokinetics/Pharmacodynamics modeling and simulation (m/f), Sophia

Bayer is an international group whose core businesses lie in the healthcare and agriculture sectors. At the intersection of chemistry and biology, Bayer helps to improve quality of life by offering products and services in human and plant health.

Missions

Give scientific support on topics within area of expertise & Participate and support interdisciplinary research projects.

• Develop physiologically-based kinetic/dynamic (PBK/D) models to characterize the dose-response curves in several organs of interest within the context of adverse outcome pathways (AOPs) in mammals
• Refine the model in close collaboration with study directors and project team members by providing input for several experimental aspects such as :in vitro and/or in vivo study designs, safety endpoints, required model parameters, and timepoints measurements
• Investigate interspecies differences
• Derive quantitative in vitro-to-in vivo extrapolations (qIVIVE)
• Collaborate and interact with an international interdisciplinary project team
• Review appropriate literature pertaining to research project
• Present and communicate study findings, results, analyses, and future direction to project partners
• Collaborate in the preparation of materials for presentation and publications

Profile

• MSc, PhD, PharmD, or equivalent in pharmacometrics, pharmaceutical sciences, mathematics, or another relevant Life Science discipline.
• Strong expertise in modeling and simulation : physiologically-based kinetic/dynamic (PBK/D) modeling required, and mechanistic TK/TD modeling would be a plus
• Broad understanding of physiology, biology, toxicology, and statistics.
• Proficiency with PK-Sim® and R required, experience with other M&S software would be a plus.
• Fluent in English (written and oral).
• Excellent communication and negotiation skills; influencing and problem solving
• Ability to work in teams across multiple regions (cultural awareness) and to work autonomously.